Dimethylformamide → methyl N-[(pent-4-enyloxy)carbonyl]-norleucinate

HRID 388218

反応式

HRID 388218 の反応式
[CH2:1]=[CH:2][CH2:3][CH:4]([OH:6])C.[C:7](N1C=CN=C1)(N1C=CN=C1)=[O:8].Cl.[CH3:20][O:21][C:22](=[O:29])[C@H:23]([CH2:25][CH2:26][CH2:27][CH3:28])[NH2:24].[CH3:30]N(C=O)C>C(OCC)C>[CH2:4]([O:6][C:7]([NH:24][C@H:23]([C:22]([O:21][CH3:20])=[O:29])[CH2:25][CH2:26][CH2:27][CH3:28])=[O:8])[CH2:3][CH2:2][CH:1]=[CH2:30]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 122474-Penten-2-OLHCID 682631,1'-CarbonyldiimidazoleHCID 14039065methyl (2S)-2-aminohexanoate hydrochloride

生成物 1

HCID 45378375methyl N-[(pent-4-enyloxy)carbonyl]-norleucinate収率 74%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 1-penten-4-ol (0.95 g, 11.0 mmol) in DMF (15 mL) at 0° C. was added carbonyldiimidazole (1.79 g, 11.0 mmol). The reaction mixture was warmed to RT and stirred for 30 minutes. L-norleucine methyl ester hydrochloride (2.0 g, 11.0 mmol) was then added, the reaction mixture was heated to 50° C. and stirred for 15 minutes. Upon cooling, the reaction mixture was diluted with ethyl ether and washed twice with water. The organic layer was dried over Na2SO4, filtered and concentrated. The crude product was purified by silica gel chromatography (gradient elution 10 to 90% EtOAc in hexanes) to afford 2.1 g (74%) methyl N-[(pent-4-en-1-yloxy)carbonyl]-L-norleucinate as a clear oil.

後処理

  1. temperaturethe reaction mixture was heated to 50° C.
  2. stirringstirred for 15 minutes
  3. temperatureUpon cooling
  4. washwashed twice with water
  5. dry with materialThe organic layer was dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe crude product was purified by silica gel chromatography (gradient elution 10 to 90% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-10c35e8ddc854de289c08d69cb8c3282
出典データセット
uspto-grants-2013_02
特許番号
US08377873B2

関連ノート

読み込み中…