Hydrazine hydrate (1:1) → 2-Methoxy-2-(naphthalen-2-yl)acetohydrazide
反応式
[CH3:1][O:2][CH:3]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[C:4](OC)=[O:5].O.[NH2:19][NH2:20]>>[CH3:1][O:2][CH:3]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1)[C:4]([NH:19][NH2:20])=[O:5]参加物
3
実験手順
A stirred solution of methyl 2-methoxy-2-(naphthalen-2-yl)acetate (0.358 g, 1 eq) and hydrazine hydrate (4 mL) was heated to reflux for 1 hour. The reaction mixture was then cooled and the solvents removed under reduced pressure. The crude oil was diluted with EtOAc and washed with H2O and the organic phase dried over Na2SO4, filtered, and the solvents removed under reduced pressure to yield a yellow oil (0.17 g, 47%) that was used without further purification.
後処理
- temperatureto reflux for 1 hour
- temperatureThe reaction mixture was then cooled
- customthe solvents removed under reduced pressure
- additionThe crude oil was diluted with EtOAc
- washwashed with H2O
- dry with materialthe organic phase dried over Na2SO4
- filtrationfiltered
- customthe solvents removed under reduced pressure
出典と根拠
- ORDレコード
- ord-65ac9737f1d540dfbe5bac6e84ee52fe
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08377930B2
反応ノート
読み込み中…