Hydrazine hydrate (1:1) → 2,2-Diphenylacetohydrazide

HRID 388258

反応式

HRID 388258 の反応式
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8](OC)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:19][NH2:20]>CCO>[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([NH:19][NH2:20])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 77019Methyl alpha-phenylbenzeneacetate

生成物 1

HCID 2261392,2-Diphenylacetohydrazide収率 97%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of methyl 2,2-diphenylacetate (0.5 g, 1 equiv) in anhydrous EtOH (150 mL) was added hydrazine hydrate (8 mL) and heated to reflux. Stirring was then continued for 1 hour. The reaction mixture was then cooled and the solvents removed under reduced pressure. The crude oil was diluted with EtOAc and washed with H2O and the organic phase dried over Na2SO4, filtered, and the solvents removed under reduced pressure to yield a yellow oil (0.97 g, 97%) that was used without further purification.

後処理

  1. temperatureheated to reflux
  2. temperatureThe reaction mixture was then cooled
  3. customthe solvents removed under reduced pressure
  4. additionThe crude oil was diluted with EtOAc
  5. washwashed with H2O
  6. dry with materialthe organic phase dried over Na2SO4
  7. filtrationfiltered
  8. customthe solvents removed under reduced pressure

出典と根拠

ORDレコード
ord-245f2a0a060f4062b6cc4b5c7f07d2ec
出典データセット
uspto-grants-2013_02
特許番号
US08377930B2

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