Trifluoroacetic acid → 6-Oxa-9-azaspiro(4.5)decane
反応式
[CH2:1]1[C:5]2([CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][O:6]2)[CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:4]1[C:5]2([CH2:10][NH:9][CH2:8][CH2:7][O:6]2)[CH2:1][CH2:2][CH2:3]1参加物
4
実験手順
To a of solution 1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate (200 mg, 0.829 mmol, available from Tyger Scientific Inc) in DCM (3 ml) was added trifluoroacetic acid (TFA) (0.5 ml). The resulting colourless yellow solution was stirred at room temperature for 24 hr. The solvent was evaporated to give the title compound as a grey oil (203 mg).
後処理
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-a356f63a3fe44678bc8ca45e60b4ef6d
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524751B2
反応ノート
読み込み中…