1-(Benzyloxy)-2,5-difluoro-4-nitrobenzene → 4-Amino-2,5-difluorophenol

HRID 388514ノート

反応式

HRID 388514 の反応式
C([O:8][C:9]1[CH:14]=[C:13]([F:15])[C:12]([N+:16]([O-])=O)=[CH:11][C:10]=1[F:19])C1C=CC=CC=1>CO.[Pd]>[NH2:16][C:12]1[C:13]([F:15])=[CH:14][C:9]([OH:8])=[C:10]([F:19])[CH:11]=1

参加物

4

反応物 1

HCID 574708681-(Benzyloxy)-2,5-difluoro-4-nitrobenzene

生成物 1

HCID 27787624-Amino-2,5-difluorophenol収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1-(benzyloxy)-2,5-difluoro-4-nitrobenzene (9.21 g) in methanol (300 ml) was added 10% palladium on carbon (921 mg), and the mixture was stirred at room temperature for 24 hours and 20 minutes under a hydrogen atmosphere. After terminating the reaction by substituting the atmosphere in the flask with nitrogen, the catalyst was filtered using Celite. The filtrate was distilled off under reduced pressure to give the title compound (4.96 g, 99%) as a brown solid.

後処理

  1. customAfter terminating
  2. customthe reaction
  3. filtrationthe catalyst was filtered
  4. distillationThe filtrate was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-9becd02f3430401c961afb6112be4201
出典データセット
uspto-grants-2013_02
特許番号
US08377938B2

反応ノート

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