Sodium Hydroxide → 2-(2,4-Difluorophenoxy)-2-methylpropanoic acid

HRID 389083ノート

反応式

HRID 389083 の反応式
[OH-].[Na+].[F:3][C:4]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:5]=1[O:6][C:7]([CH3:14])([CH3:13])[C:8]([O:10]CC)=[O:9]>CO>[F:3][C:4]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:5]=1[O:6][C:7]([CH3:14])([CH3:13])[C:8]([OH:10])=[O:9]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 1531792HCID 1531792、化合物

生成物 1

HCID 15318012-(2,4-Difluorophenoxy)-2-methylpropanoic acid収率 98.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

An aqueous sodium hydroxide solution (22.4 ml) was added to a solution of ethyl 2-(2,4-difluorophenoxy)-2-methylpropanoate (2.74 g) in methanol (27.4 ml) under ice cooling, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, 1M hydrochloric acid was added thereto followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to obtain 2-(2,4-difluorophenoxy)-2-methylpropanoic acid (2.38 g) as a colorless oily product.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure, 1M hydrochloric acid
  2. additionwas added
  3. extractionthereto followed by extraction with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d64fa650d73541fd8fcda35d3e81a274
出典データセット
uspto-grants-2013_02
特許番号
US08377923B2

反応ノート

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