Triethylsilane → 2,3-Dihydro-4,7-dimethoxy-1H-indene
反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=O.C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4]2[C:8]=1[CH2:7][CH2:6][CH2:5]2参加物
4
実験手順
To the cooled and stirred suspension of 4,7-Dimethoxyindan-1-one (35 gm, 0.182 mole) in Triethyl silane (105.7 gm, 0.909 mole), added Trifluoroacetic acid (350 ml) at 10-15° C. The stirring was continued at room temperature for 2 hours and quenched into the water. It was extracted with Ethyl acetate. The Ethyl acetate layer was washed with Sodium bicarbonate solution, dried over Sodium sulphate and evaporated to give crude mass which was purified by column chouromatography using 5% Ethyl acetate in hexane (22.5 gm).
後処理
- temperatureTo the cooled
- customquenched into the water
- extractionIt was extracted with Ethyl acetate
- washThe Ethyl acetate layer was washed with Sodium bicarbonate solution
- dry with materialdried over Sodium sulphate
- customevaporated
- customto give crude mass which
- customwas purified by column chouromatography
出典と根拠
- ORDレコード
- ord-b02e0f252d6443fe8f380246ef849ad5
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08378118B2
反応ノート
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