8-Methylcoumarin → 8-Methyl-3,4-dihydrocoumarin

HRID 389311

反応式

HRID 389311 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH:8]=[CH:7]2.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH2:8][CH2:7]2

参加物

5

反応物 2

HCID 157348-MethylcoumarinHCID 178418361HCID 178418361、化合物

生成物 1

HCID 235130958-Methyl-3,4-dihydrocoumarin収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 8-Methyl coumarin (16.2 gm) in Ethyl acetate (160 ml), 10% w/w Palladium-charcoal (1.62 gm) was added. Hydrogenation was carried out for 5 hours at 55-60° C. in an autoclave at 240-250 psi. using Hydrogen gas. The reaction mixture was filtered through hyflow bed and distilled under vacuum to give a 14.5 gm of title compound as a white solid.

後処理

  1. filtrationThe reaction mixture was filtered through hyflow bed
  2. distillationdistilled under vacuum

出典と根拠

ORDレコード
ord-eb1ea88eeb3a45139e9622bcf3cf4c15
出典データセット
uspto-grants-2013_02
特許番号
US08378118B2

関連ノート

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