[CH3:1][C:2]1[CH:3]=[C:4]([CH:12]=[O:13])[C:5]2[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[OH:11].[C:14](=O)([O-])[O-].[K+].[K+].CI.O>CN(C)C=O>[CH3:14][O:11][C:10]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[C:4]([CH:12]=[O:13])=[CH:3][C:2]=1[CH3:1]To a stirred suspension of 6-Methyl-7-hydroxy-indan-4-carbaldehyde (5 gm, 0.0284 mole) and Potassium carbonate (4.7 gm, 0.0340 mole) in dimethyl formamide, Methyl iodide (2.2 ml, 0.0312 mole) was added at 0° C. The reaction mixture was stirred at 25-30° C. for 4 hours, then water (200 ml) was added and extracted with Ethylacetate (2×100 ml). The Ethylacetate layer was dried over Sodium sulphate and evaporated to give a crude mass which was purified by column chromatography using Ethyl acetate:Hexane (10:90) as a mobile phase. The fractions were distilled under vacuum to give 4.8 gm of desired product as viscous oil.
読み込み中…
