N-Methylethylamine → N-{[5-Fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}-N-methylethanamine

HRID 38936

反応式

HRID 38936 の反応式
[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12]OS(C3C=CC(C)=CC=3)(=O)=O)[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[CH3:28][NH:29][CH2:30][CH3:31]>C(#N)C>[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12][N:29]([CH3:28])[CH2:30][CH3:31])[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:25])=[O:26])[CH:3]=1

参加物

4

反応物 2

HCID 12219N-MethylethylamineHCID 86652936[5-Fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

生成物 1

HCID 44470015N-{[5-Fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}-N-methylethanamine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), N-methylethanamine (0.5 ml), ACN (1 ml). MS m/z (rel. intensity, 70 eV) 303 (M+, 0.5), 84 (2), 73 (4), 72 (bp), 69 (2).

後処理

  1. customPreparation

出典と根拠

ORDレコード
ord-50f1173cba8f414795f0f73418295756
出典データセット
uspto-grants-2013_09
特許番号
US08524766B2

関連ノート

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