Water → (2S,3R,4S)-2,3,4-Trihydroxycyclohexanone

HRID 389374ノート

反応式

HRID 389374 の反応式
[OH:1][C@@H:2]1[C@@H:7]([OH:8])[C@H:6]([OH:9])[C:5](=[O:10])[CH:4]=[CH:3]1.O>CO.[Pd]>[OH:8][C@H:7]1[C@H:6]([OH:9])[C@@H:5]([OH:10])[CH2:4][CH2:3][C:2]1=[O:1]

参加物

5

反応物 2

HCID 962WaterHCID 44511908HCID 44511908、化合物

生成物 1

HCID 45082801(2S,3R,4S)-2,3,4-Trihydroxycyclohexanone収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

205 mg of (4S,5R,6S)-4,5,6-trihydroxy-2-cyclohexene-1-one obtained in Example 3 was dissolved in 3.5 mL of methanol. 20 mg (50 weight % of water contained) of 5 weight % Pd/C was added thereto and hydrogenated at room temperature (25 degrees centigrade) under ordinary pressure (1 atm). After the completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to obtain 198 mg (yield: 96%) of (2S,3R,4S)-2,3,4-trihydroxycyclohexane-1-one.

後処理

  1. customhydrogenated at room temperature
  2. custom(25 degrees centigrade)
  3. customAfter the completion of the reaction
  4. customthe catalyst was removed by filtration
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-c25bac5a1b794539b0ff197a9ac631f9
出典データセット
uspto-grants-2013_02
特許番号
US08378146B2

反応ノート

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