N-Methylethylamine → N-Methyl-N-{[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}ethanamine

HRID 38974

反応式

HRID 38974 の反応式
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:18][CH:19]=3)[O:14]2)(=O)=O)=CC=1.[CH3:27][NH:28][CH2:29][CH3:30].CC(C)(C)CNC[C@@H]1OC2C=C(S(C)(=O)=O)C=CC=2OC1>C(#N)C>[CH3:27][N:28]([CH2:12][CH:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:24])=[O:25])=[CH:18][CH:19]=2)[O:14]1)[CH2:29][CH3:30]

参加物

5

反応物 3

HCID 12219N-MethylethylamineHCID 444683782,2-Dimethyl-N-{[(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}propan-1-amineHCID 86652940[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate

生成物 1

HCID 44468652N-Methyl-N-{[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}ethanamine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Preparation according to Example 25: [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0504 mmol), N-methylethanamine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 283 (M+, 2), 131 (4), 77 (4), 73 (5), 72 (bp), 63 (2).

後処理

  1. customPreparation

出典と根拠

ORDレコード
ord-c71b1b288cd343e089c69a7a28d1386f
出典データセット
uspto-grants-2013_09
特許番号
US08524766B2

関連ノート

読み込み中…