Water → 2-Hydroxy-3'-(trifluoromethyl)acetophenone

HRID 389890ノート

反応式

HRID 389890 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[OH2:15]>C(#N)C>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][OH:15])[CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 962WaterHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

生成物 1

HCID 167269582-Hydroxy-3'-(trifluoromethyl)acetophenone

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (1 g) in acetonitrile (2.5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated five times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

後処理

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-ba55c46c5d4f44f2a5e9f3d295235304
出典データセット
uspto-grants-2013_02
特許番号
US08383608B2

反応ノート

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