3-Methylacetophenone → 2-Bromo-1-(3-methylphenyl)ethan-1-one
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Br:11]Br.C(=O)(O)[O-].[Na+]>C(OCC)C>[Br:11][CH2:9][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:10]参加物
5
実験手順
To a solution of 1-(3-methylphenyl)ethanone (2 g) in ethyl ether (20 mL) is added bromine (726 μL) at 0° C. The mixture is treated with an aqueous solution of sodium bicarbonate, extracted with ethyl ether, dried over magnesium sulfate, concentrated and purified on silica gel (ethyl acetate/cyclohexane 0/100) to give the desired compound.
後処理
- extractionextracted with ethyl ether
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
- custompurified on silica gel (ethyl acetate/cyclohexane 0/100)
出典と根拠
- ORDレコード
- ord-6dd5181a9b7a47fb8fad3019836c489d
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383608B2
反応ノート
読み込み中…