2-bromo-N-(pyrazin-2-yl)acetamide → 3-Hydroxy-1-methyl-1-(pyrazin-2-ylcarbamoylmethyl)-pyrrolidinium bromide
反応式
[Br:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)=[O:4].[OH:12][C@@H:13]1[CH2:17][CH2:16][N:15]([CH3:18])[C:14]1=O>C(#N)C>[Br-:1].[OH:12][CH:13]1[CH2:17][CH2:16][N+:15]([CH3:18])([CH2:2][C:3](=[O:4])[NH:5][C:6]2[CH:11]=[N:10][CH:9]=[CH:8][N:7]=2)[CH2:14]1参加物
4
実験手順
A solution of 2-Bromo-N-pyrazin-2-yl-acetamide (Intermediate A)(3.0 g, 13.9 mmol) in acetonitrile (80 ml) is treated with (R)-hydroxy-methyl pyrrolidone (1.4 g, 13.9 mmol). The resulting suspension is stirred at room temperature for 3 hours and then filtered. The solid is washed with acetonitrile and dried in vacuo overnight to yield the titled compound as a brown solid.
後処理
- filtrationfiltered
- washThe solid is washed with acetonitrile
- customdried in vacuo overnight
出典と根拠
- ORDレコード
- ord-316d80e5adb94f3f8f144316b110b54e
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383625B2
反応ノート
読み込み中…