1-Methyl-3-pyrrolidinol, (-)- → (R)-3-Hydroxy-1-methyl-1-(pyridazin-3-ylcarbamoylmethyl)-pyrrolidinium bromide
反応式
[Br:1][CH2:2][C:3]([NH:5][C:6]1[N:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[OH:12][C@@H:13]1[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14]1>C(#N)C>[Br-:1].[OH:12][CH:13]1[CH2:17][CH2:16][N@@+:15]([CH3:18])([CH2:2][C:3](=[O:4])[NH:5][C:6]2[N:7]=[N:8][CH:9]=[CH:10][CH:11]=2)[CH2:14]1参加物
4
実験手順
A stirred suspension of 2-bromo-N-pyridazin-3-yl-acetamide (0.5 g, 2.31 mmol) in acetonitrile (10 ml) is treated with (R)-3-hydroxy-1-methyl pyrrolidine (0.234 g, 2.31 mmol). The suspension is stirred at room temperature for 2 hours and then filtered and washed with acetonitrile to yield the titled compound.
後処理
- filtrationfiltered
- washwashed with acetonitrile
出典と根拠
- ORDレコード
- ord-76142c7e79534258ad41ca5c98de419c
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383625B2
反応ノート
読み込み中…