Sodium Hydroxide → HCID 66879256、化合物

HRID 39006ノート

反応式

HRID 39006 の反応式
C([O:4][C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[C:7]([F:12])[C:6]=1[O:13][CH2:14][C@H:15]1[CH2:17][O:16]1)(=O)C.[OH-].[Na+]>O1CCOCC1>[Br:11][C:9]1[CH:8]=[C:7]([F:12])[C:6]2[O:13][CH2:14][C@H:15]([CH2:17][OH:16])[O:4][C:5]=2[CH:10]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 866529465-Bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate

生成物 1

HCID 66879256HCID 66879256、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

1-(5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate (crude, max 67 mmol) was stirred in dioxane at 0° C. NaOH (15%) was added until the mixture reached pH 14. The mixture was stirred for 30 min at RT and then concentrated. Water was added and the mixture extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated to dryness to give the crude title compound. Yield: 10.3 g. MS m/z (rel. intensity, 70 eV) 262 (M+, bp), 264 (M+, bp), 206 (70), 81 (58), 69 (55), 57 (53).

後処理

  1. concentrationconcentrated
  2. additionWater was added
  3. extractionthe mixture extracted with EtOAc
  4. washThe combined organic phases were washed with brine
  5. dry with materialdried (Na2SO4)
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-32a2f494200a4a5bbc14c29820a1e1b8
出典データセット
uspto-grants-2013_09
特許番号
US08524766B2

反応ノート

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