N-bromobutanimide → HCID 58296328、化合物

HRID 390062ノート

反応式

HRID 390062 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:10]3[C:20](=[O:21])[NH:19][CH:18]=[CH:17][C:11]=3[N:12]=[C:13]([S:15][CH3:16])[N:14]=2)[CH:5]=[CH:6][CH:7]=1.C1C(=O)N([Br:29])C(=O)C1>CN(C)C=O>[Br:29][C:17]1[C:11]2[N:12]=[C:13]([S:15][CH3:16])[N:14]=[C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=3)[C:10]=2[C:20](=[O:21])[NH:19][CH:18]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 58296312HCID 58296312、化合物

生成物 1

HCID 58296328HCID 58296328、化合物収率 83%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one (500 mg, 1.676 mmol) was dissolved into N,N-Dimethylformamide (DMF) (8 mL) and NBS (298 mg, 1.676 mmol) was added. The reaction mixture was stirred at rt for 2 h. It was quenched with water (12 mL) and EtOAc (5 mL) was added. The mixture was filtered to collect the precipitate, which was further dried under high vacuum to give 470 mg of crude product (83% pure based on LC-MS).

後処理

  1. additionwas added
  2. customIt was quenched with water (12 mL) and EtOAc (5 mL)
  3. additionwas added
  4. filtrationThe mixture was filtered
  5. customto collect the precipitate, which
  6. customwas further dried under high vacuum

出典と根拠

ORDレコード
ord-73345933f8024366b423f3153a7150da
出典データセット
uspto-grants-2013_02
特許番号
US08383635B2

反応ノート

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