Trifluoroacetic acid → HCID 44623930、化合物
反応式
[CH3:1][N:2]([CH2:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[N:19]=[C:20]([NH:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[CH:31]=2)[C:21]2[C:27](=[O:28])[NH:26][CH:25]=[CH:24][C:22]=2[N:23]=1)=[O:12])C(=O)OC(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][NH:2][CH2:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[N:19]=[C:20]([NH:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[CH:31]=2)[C:21]2[C:27](=[O:28])[NH:26][CH:25]=[CH:24][C:22]=2[N:23]=1)=[O:12]参加物
4
実験手順
To a solution of 1,1-dimethylethyl methyl(2-{[3-({4[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]amino}-2-oxoethyl)carbamate (30 mg, 0.061 mmol) in Dichloromethane (DCM) (1 mL) was added TFA (0.5 mL, 6.49 mmol), and the reaction mixture was stirred for 1.5 h. It was concentrated and the residue was further dried under high vacuum to give 30 mg of pure product.