Pyridine → 4-[(Trifluoromethyl)sulfonyl]phenyl acetate

反応式

[F:1][C:2]([F:14])([F:13])[S:3]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)(=[O:5])=[O:4].[C:15](OC(=O)C)(=[O:17])[CH3:16].N1C=CC=CC=1>>[C:15]([O:12][C:9]1[CH:8]=[CH:7][C:6]([S:3]([C:2]([F:13])([F:1])[F:14])(=[O:4])=[O:5])=[CH:11][CH:10]=1)(=[O:17])[CH3:16]

参加物

反応物 3

HCID 1049Pyridine

HCID 7918Acetic Anhydride

HCID 148574264-Trifluoromethanesulfonylphenol

生成物 1

HCID 672004354-[(Trifluoromethyl)sulfonyl]phenyl acetate

実験手順

Preparation according to Preparation 16 using 4-[(trifluoromethyl)sulfonyl]phenol (4.5 g, 23.2 mmol), acetic anhydride (13.4 g, 130 mmol) and pyridine (10.6 ml, 130 mmol). Crude yield: 6.8 g. MS m/z (rel. intensity, 70 eV) 268 (M+, 6), 157 (bp), 93 (84), 65 (52), 64 (43).