7-bromo-2',3'-dihydro-1'H-spiro[isoindoline-1,4'-pyridin]-3-one → 7-Bromospiro[isoindoline-1,4'-piperidin]-3-one

HRID 390138ノート

反応式

HRID 390138 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:15]=1[C:9]1([CH:14]=[CH:13][NH:12][CH2:11][CH2:10]1)[NH:8][C:7]2=[O:16]>CC(O)=O.O=[Pt]=O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:15]=1[C:9]1([CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[NH:8][C:7]2=[O:16]

参加物

4

反応物 1

HCID 582957447-bromo-2',3'-dihydro-1'H-spiro[isoindoline-1,4'-pyridin]-3-one

生成物 1

HCID 582957267-Bromospiro[isoindoline-1,4'-piperidin]-3-one収率 100%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

A solution of 7-bromo-2′,3′-dihydro-1′H-spiro[isoindoline-1,4′-pyridin]-3-one (2 g, 0.0072 mol) in CH3COOH was hydrogenated in the presence of PtO2 for 1.5 h. The catalyst was removed by filtration and the filtrate was concentrated to give the crude product which was washed with saturated aq Na2CO3. The solvent was removed to give the 7-bromospiro[isoindoline-1,4′-piperidin]-3-one (2 g, 100%).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customto give the crude product which
  4. washwas washed with saturated aq Na2CO3
  5. customThe solvent was removed

出典と根拠

ORDレコード
ord-fa458ef465bd4795b4d1554c03548242
出典データセット
uspto-grants-2013_02
特許番号
US08383629B2

反応ノート

読み込み中…