Ammonium Hydroxide → Ethyl [5-(5-bromo-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl]acetate

反応式

[Br:1][C:2]1[S:6][C:5]([C:7]([NH2:9])=O)=[N:4][N:3]=1.BrC1S[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:13][N:12]=1.[NH4+:21].[OH-]>C1COCC1>[Br:1][C:2]1[S:6][C:5]([C:7]2[N:9]=[N:12][N:13]([CH2:14][C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:21]=2)=[N:4][N:3]=1

参加物

実験手順

5-Bromo-1,3,4-thiadiazole-2-carboxamide To a solution of ethyl 5-bromo-1,3,4-thiadiazole-2-carboxylate in THF (1.1 M) at room temperature was added concentrated NH4OH (2.9 equiv). The mixture was stirred at room temperature overnight and a precipitate appeared in the aqueous layer. Then the volatile solvent was removed in vacuo. The resulting mixture was diluted with water and the precipitate was collected, washed with water and dried under vacuum to give the title compound.