Triethylamine → Ethyl [5-(5-bromo-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl]acetate
反応式
[Br:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[N:4][N:3]=1.BrC1SC(C(N)=O)=[N:12][N:11]=1.CC[N:20](CC)CC.[C:25]([O:31][C:32]([C:34](F)(F)F)=O)([C:27](F)(F)F)=[O:26]>C1COCC1>[Br:1][C:2]1[S:6][C:5]([C:7]2[N:20]=[N:11][N:12]([CH2:27][C:25]([O:31][CH2:32][CH3:34])=[O:26])[N:8]=2)=[N:4][N:3]=1参加物
6
実験手順
5-Bromo-1,3,4-thiadiazole-2-carbonitrile To a solution of 5-bromo-1,3,4-thiadiazole-2-carboxamide and Et3N (2.3 equiv) in THF (0.5 M) at 0° C. was added TFAA (1.1 equiv). The mixture was then warmed to room temperature and stirred for 30 min, then the solvent was evaporated in vacuo. The resulting residue was diluted with water. The resulting precipitate was collected, washed with water, and dried to give the title compound.
後処理
- customthe solvent was evaporated in vacuo
- additionThe resulting residue was diluted with water
- customThe resulting precipitate was collected
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-ceded20fa0854a9f830da425584a44db
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383643B2
反応ノート
読み込み中…