Trifluoroacetic acid → 2-(5-Bromobenzo[d]oxazole-2-carboxamido)-4-(4-chlorophenyl)thiophene-3-carboxylic acid

HRID 390777ノート

反応式

HRID 390777 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([NH:12][C:13]3[S:14][CH:15]=[C:16]([C:25]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=4)[C:17]=3[C:18]([O:20]C(C)(C)C)=[O:19])=[O:11])=[N:7][C:6]=2[CH:32]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([NH:12][C:13]3[S:14][CH:15]=[C:16]([C:25]4[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=4)[C:17]=3[C:18]([OH:20])=[O:19])=[O:11])=[N:7][C:6]=2[CH:32]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67207536Tert-butyl 2-(5-bromobenzo[d]oxazole-2-carboxamido)-4-(4-chlorophenyl)thiophene-3-carboxylate

生成物 1

HCID 595359892-(5-Bromobenzo[d]oxazole-2-carboxamido)-4-(4-chlorophenyl)thiophene-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3A in DCM (2 ml) at room was added TFA (2 ml). The mixture was stirred at room temperature for 30 minutes. The solvent was removed under vacuum. The residue was suspended in DCM (1 ml). The solid was collected by filtration, washed with DCM (3×1 ml) and dried to give 4A. 1H NMR (DMSO-d6) δ 7.12 (s, 1H), 7.38 (d, 2H), 7.43 (d, 2H), 7.79 (dd, 1H), 7.96 (d, 1H), 8.29 (d, 1H), 12.80 (bs, 1H), 13.44 (b, 1H).

後処理

  1. customThe solvent was removed under vacuum
  2. filtrationThe solid was collected by filtration
  3. washwashed with DCM (3×1 ml)
  4. customdried

出典と根拠

ORDレコード
ord-e4b1f33ff35940938516770c267fb1e6
出典データセット
uspto-grants-2013_02
特許番号
US08383670B2

反応ノート

読み込み中…