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HRID 390942作成日：2026年10月25日

2-Methoxypyrimidine-5-boronic acid → 2-(2-methoxypyrimidin-5-yl)-4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidine

https://huagongshe.com/reaction/390942

反応式

関与物質

役割名称HCID仕込み量
反応物2-Methoxypyrimidine-5-boronic acidHCID 2736778—
反応物2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidineHCID 56833744—
生成物2-(2-methoxypyrimidin-5-yl)-4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidineHCID 58233957—

反応手順

2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine (Example 153) was reacted with 2-methoxypyrimidine-5-boronic acid via General Procedure E to give, after purification by reverse HPLC, 4 mg of 237. MS (Q1) 490 (M+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08383620B2
出典データセットuspto-grants-2013_02
ORD IDord-c9d877905fa840edb3c2923cab37cfb1
出典メモuspto-grants-2013_02