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HRID 390943作成日：2026年10月25日

5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbaldehyde → 5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidin-2-yl)pyridine-3-carbaldehyde

https://huagongshe.com/reaction/390943

反応式

関与物質

役割名称HCID仕込み量
反応物5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbaldehydeHCID 4992640—
反応物2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidineHCID 56833744—
生成物5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)furo[3,2-d]pyrimidin-2-yl)pyridine-3-carbaldehydeHCID 58234012—

反応手順

2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinofuro[3,2-d]pyrimidine (Example 153) was reacted with 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-3-carbaldehyde via General Procedure E to give, after purification by reverse HPLC, 11 mg of 238. MS (Q1) 487 (M+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08383620B2
出典データセットuspto-grants-2013_02
ORD IDord-3a09b569a7b4416b950941f3c96e30a8
出典メモuspto-grants-2013_02