Sodium borohydride → (5-Bromopyridin-2-yl)methanol

To a solution of 5-bromopyridine-2-carbaldehyde (300 mg) in methanol (10 mL) was added sodium borohydride (61 mg) and the reaction stirred at room temperature for 72 h. The reaction was quenched with saturated aqueous sodium carbonate solution (20 mL) and water (20 mL) and extracted into dichloromethane (3×30 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-methanol as a white solid.

1. customThe reaction was quenched with saturated aqueous sodium carbonate solution (20 mL) and water (20 mL)
2. extractionextracted into dichloromethane (3×30 mL)
3. dry with materialThe organic layers were dried (MgSO4)

ORDレコード

ord-d50072c653d44d7ea55d70ddb7fd33ee

出典データセット

uspto-grants-2013_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08383620B2