1-(4-Iodophenyl)ethan-1-one → (s)-5-[(4-Acetylphenyl)ethynyl]-n-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

HRID 391524

反応式

HRID 391524 の反応式
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=1)[C:8]([N:10]=[S@@:11]([CH3:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])#[CH:2].[CH3:21][C:22]([C:24]1[CH:29]=[CH:28][C:27](I)=[CH:26][CH:25]=1)=[O:23]>>[C:22]([C:24]1[CH:29]=[CH:28][C:27]([C:2]#[C:1][C:3]2[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=2)[C:8]([N:10]=[S@@:11]([CH3:19])(=[O:18])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:9])=[CH:26][CH:25]=1)(=[O:23])[CH3:21]

参加物

3

反応物 2

HCID 728691-(4-Iodophenyl)ethan-1-oneHCID 24953136(S)-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

生成物 1

HCID 24953842(s)-5-[(4-Acetylphenyl)ethynyl]-n-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide収率 86%

実験手順

In a manner similar to that describe in Example 434 a mixture of (S)-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 4-iodoacetophenone were reacted to give the title compound as a light yellow foam (52 mg, 86%).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-81b5eb7fe2d143c6900463b22a74d1ce
出典データセット
uspto-grants-2013_02
特許番号
US08383825B2

関連ノート

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