Thionyl Chloride → HCID 10879289、化合物

HRID 392060ノート

反応式

HRID 392060 の反応式
[CH:1]1[C:14]2[N:13]([CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)S[C:5]=2[CH:4]=[CH:3][CH:2]=1.N=CCCC(CC1C=CC=CC=1)(CC1C=CC=CC=1)O.S(Cl)(Cl)=O>C1C=CC=CC=1>[C:12]1([N:13]([C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][CH:5]=2)[CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 1114022010H-Phenothiazine-10-butanolHCID 22662683HCID 22662683、化合物

生成物 1

HCID 10879289HCID 10879289、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To prepare compounds 6a, 6b and 6e, to a solution of 5a (2.03 g, 7.5 mmol), 5b or 5e in 100 ml of dry benzene was added thionyl chloride (2 ml, 10 mmol) and stirred overnight at room temperature. After solvent evaporation, the residue was chromatographed on silica gel column. Elution with 10% ethyl acetate/hexanes afforded the following compounds:

後処理

  1. customAfter solvent evaporation
  2. customthe residue was chromatographed on silica gel column
  3. washElution with 10% ethyl acetate/hexanes
  4. customafforded the following compounds

出典と根拠

ORDレコード
ord-735e3cac9b934c0f8773f833d4f12b59
出典データセット
uspto-grants-2004_10
特許番号
US06800618B2

反応ノート

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