Methyl iodide → HCID 22663158、化合物

反応式

[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[C:17]([NH:29][CH3:30])[N:16]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:31]I>>[CH2:1]([N:8]([C:9]1[CH:10]=[C:11]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[C:17]([NH:29][CH3:30])[N:16]=2)[CH:12]=[CH:13][CH:14]=1)[CH3:31])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 6328Methyl iodide

HCID 22663144HCID 22663144、化合物

生成物 1

HCID 22663158HCID 22663158、化合物収率 33.8%

実験手順

Starting from 100 mg of 4-(3-benzylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline obtained in Example 38 and 71.0 mg of methyl iodide, 35.0 mg of the title compound was obtained as a pale yellow oil in the same manner as in Example 38.

出典と根拠

ORDレコード: ord-ecbea7fe94a94c6b95821af69bfa1d0a
出典データセット: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06800644B2

反応ノート

読み込み中…