2-Fluorophenol → HCID 69880868、化合物

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23]>>[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 97072-Fluorophenol

HCID 7427744-bromo-N-(pyridin-3-ylmethyl)aniline

生成物 1

HCID 69880868HCID 69880868、化合物

実験手順

Using the method of Example 342 using N-(4-bromophenyl)pyridin-3-ylmethylamine and 2-fluorophenol (Aldrich)and purifying via preparative HPLC eluting with 90:10 to 80:20 DCM/ethyl acetate gave N-(4-(2-fluorophenoxy)phenyl)pyrid-3-ylmethylamine. Anal Calcd for C18H15FN2O: C, 73.45; H, 5.14; N, 9.52. Found: C, 73.36; H, 5.22; N, 9.35. MS found 295.1 [M+H]+

後処理

custompurifying via preparative HPLC
washeluting with 90:10 to 80:20 DCM/ethyl acetate

出典と根拠

ORDレコード: ord-25cfcd47a3e3473093357d9d679fd19e
出典データセット: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06800651B2

反応ノート

読み込み中…