Dichloromethane → Propionyloxyacetyl chloride
反応式
S(Cl)(Cl)=[O:2].C(=O)(O[CH2:10][O:11][C:12](=[O:15])[CH2:13][CH3:14])SCC.[CH2:17]([Cl:19])Cl>>[C:12]([O:11][CH2:10][C:17]([Cl:19])=[O:2])(=[O:15])[CH2:13][CH3:14]参加物
4
実験手順
Thionyl chloride (101 μL, 1.25 mmol) was added drop-wise to a solution of 53 (160 mg, 0.832 mmol) in CH2Cl2 (0.5 mL) at 0° C. then the solution was stirred for a further 1.5 hr. The solvent was removed under reduced pressure resulting in the volatile chloroformate 54 (138 mg, 100%). 1H NMR (400 MHz, CDCl3) δ 1.18 (t, J=7.4, 3H), 2.45 (q, J=7.4, 2H), 5.83 (s, 2H).
後処理
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-fa376d4a030d486f8a0a3fc9721affc8
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524691B2
反応ノート
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