Formic Acid → HCID 178487492、化合物

HRID 392580

反応式

HRID 392580 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([C:15]1[N:16]=[CH:17][N:18](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:19]=1)=[O:14])[CH:7]=[CH:6]2.C(O)=O.[CH2:42]1[CH2:46]OC[CH2:43]1>>[NH:18]1[CH:19]=[C:15]([C:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:9]=2)([OH:14])[CH:42]([CH3:46])[CH3:43])[N:16]=[CH:17]1

参加物

4

反応物 3

HCID 284Formic AcidHCID 8028TetrahydrofuranHCID 11733735(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone

生成物 1

HCID 178487492HCID 178487492、化合物

反応条件

温度
50 °C

実験手順

(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone (15.0 g) was dissolved in THF (80 ml) and 90% formic acid (20 ml) was added. The mixture was stirred at 50° C. for 2 h and the solvent was evaporated. 1N Hydrochloric acid (60 ml) was added and the precipitate was filtrated. The filtrate was washed with ether and neutralized with potassium carbonate. The resulting precipitate was collected by filtration and dried under reduced pressure to give the title compound (7.54 g) as a colorless solid.

後処理

  1. customthe solvent was evaporated
  2. addition1N Hydrochloric acid (60 ml) was added
  3. filtrationthe precipitate was filtrated
  4. washThe filtrate was washed with ether and neutralized with potassium carbonate
  5. filtrationThe resulting precipitate was collected by filtration
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-acd1013aaac349c5bb3de64a8bc69a98
出典データセット
uspto-grants-2004_10
特許番号
US06800778B1

関連ノート

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