Piperidine → Phe-Gly

HRID 39263

反応式

HRID 39263 の反応式
C1C2C(COC([NH:18][C@H:19]([C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:18][C@H:19]([C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

4

反応物 2

HCID 8082PiperidineHCID 11328236Fmoc-Phe-Gly-OH

生成物 1

HCID 6992304Phe-Gly

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Fmoc-protected dipeptide 72 (500 mg, 1.00 mmol) was treated with a 5% v/v solution of piperidine in DMF (5 mL). After stirring for 1 h, the reaction mixture was concentrated to dryness. The crude material was used for the next step without purification.

後処理

  1. concentrationthe reaction mixture was concentrated to dryness
  2. customThe crude material was used for the next step without purification

出典と根拠

ORDレコード
ord-f2ae1b8090a940d2913985de4b8df854
出典データセット
uspto-grants-2013_09
特許番号
US08524691B2

関連ノート

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