Piperidine → Glycyl-phenylalanyl-glycine

HRID 39265

反応式

HRID 39265 の反応式
C1C2C(COC([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:32])[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:21])=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21]

参加物

4

反応物 2

HCID 8082PiperidineHCID 15222489N-Fmoc-glycyl-L-phenylalanyl-glycine

生成物 1

HCID 6992441Glycyl-phenylalanyl-glycine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Fmoc-protected tripeptide 74 (546 mg, 0.98 mmol) was treated with a 5% v/v solution of piperidine in DMF (5 mL). After stirring for 45 min, the reaction mixture was concentrated to dryness. The crude material was used for the next step without purification.

後処理

  1. concentrationthe reaction mixture was concentrated to dryness
  2. customThe crude material was used for the next step without purification

出典と根拠

ORDレコード
ord-7e66b13904154ebcbe524b75757fe2f1
出典データセット
uspto-grants-2013_09
特許番号
US08524691B2

関連ノート

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