Acetyl chloride → N-biphenyl-3-ylmethyl-acetamide

HRID 392830

反応式

HRID 392830 の反応式
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH2:8])[CH:2]=1.C([O-])(O)=O.[Na+].[C:20](Cl)(=[O:22])[CH3:21]>C(Cl)Cl>[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:20](=[O:22])[CH3:21])[CH:2]=1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 516892Sodium BicarbonateHCID 27603683-(Aminomethyl)biphenyl

生成物 1

HCID 22660935N-biphenyl-3-ylmethyl-acetamide収率 128.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

C-Biphenyl-3-yl-methylamine (700 mg, 3.8 mmol) was dissolved in 38 mL of CH2Cl2. To this was added 38 mL of satd NaHCO3 (aq) followed by acetyl chloride (1.41 mL 19,8 mmol). The resulting mixture was stirred 45 min. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed under vacuum to yield 1.1 grams of N-biphenyl-3-ylmethyl-acetamide.

後処理

  1. customThe organic layer was separated
  2. washwashed with satd NaCl
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customsolvent removed under vacuum

出典と根拠

ORDレコード
ord-dedfeb76dab54b4b9c853a25bd0c6433
出典データセット
uspto-grants-2004_10
特許番号
US06803378B2

関連ノート

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