Acetyl chloride → N-biphenyl-3-ylmethyl-acetamide
反応式
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH2:8])[CH:2]=1.C([O-])(O)=O.[Na+].[C:20](Cl)(=[O:22])[CH3:21]>C(Cl)Cl>[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:20](=[O:22])[CH3:21])[CH:2]=1参加物
5
実験手順
C-Biphenyl-3-yl-methylamine (700 mg, 3.8 mmol) was dissolved in 38 mL of CH2Cl2. To this was added 38 mL of satd NaHCO3 (aq) followed by acetyl chloride (1.41 mL 19,8 mmol). The resulting mixture was stirred 45 min. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed under vacuum to yield 1.1 grams of N-biphenyl-3-ylmethyl-acetamide.
後処理
- customThe organic layer was separated
- washwashed with satd NaCl
- dry with materialdried over Na2SO4
- filtrationfiltered
- customsolvent removed under vacuum
出典と根拠
- ORDレコード
- ord-dedfeb76dab54b4b9c853a25bd0c6433
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06803378B2
反応ノート
読み込み中…