Trifluoroacetic acid → HCID 86655584、化合物

HRID 39284

反応式

HRID 39284 の反応式
C([N:8]([C:20](=[O:54])[CH2:21][CH2:22][C:23]1[C:28]([CH3:29])=[C:27]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]([P:42]([CH2:46][CH3:47])([CH2:44][CH3:45])=[O:43])[P:36]([CH2:40][CH3:41])([CH2:38][CH3:39])=[O:37])[C:26]([CH3:48])=[CH:25][C:24]=1[O:49][C:50](=[O:53])[CH2:51][CH3:52])[C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C1C=CC=CC=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:50]([O:49][C:24]1[CH:25]=[C:26]([CH3:48])[C:27]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]([P:36]([CH2:38][CH3:39])([CH2:40][CH3:41])=[O:37])[P:42]([CH2:44][CH3:45])([CH2:46][CH3:47])=[O:43])=[C:28]([CH3:29])[C:23]=1[CH2:22][CH2:21][C:20]([NH:8][C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:54])(=[O:53])[CH2:51][CH3:52]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86655583Benzyl N-(3-(2-propionyloxy-4,6-dimethyl-5-(5,5-bis(diethylphosphoryl)pentyloxy)phenyl)propanoyl)-L-phenylalanine

生成物 1

HCID 86655584HCID 86655584、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Compound 135 (272 mg, 0.335 mmol) was treated with a 50% v/v solution of TFA in CH2Cl2 (4 mL). After stirring for 3 hr the reaction mixture was concentrated to dryness and coevaporated with toluene. After drying under vacuum, acid 136 was obtained as a colorless liquid (304 mg, 120%) and was used without purification. 1H NMR (400 MHz, CDCl3) δ 1.25 (t, J=7.3, 3H), 1.32-1.37 (m, 12H), 1.70-1.81 (m, 4H), 1.93-2.02 (m, 2H), 2.13 (s, 3H), 2.20 (s, 3H), 2.20-2.29 (m, 2H), 2.47 (tt, J=5.8, 24.5, 1H), 2.57 (q, J=7.7, 2H), 2.74-2.81 (m, 1H), 2.87-2.93 (m, 1H), 3.01 (dd, J=6.2, 14.0, 1H), 3.15 (dd, J=5.5, 14.0, 1H), 3.66 (t, J=6.8, 2H), 4.14-4.22 (m, 8H), 4.75-4.80 (m, 1H), 6.12 (d, J=7.6, 1H), 6.67 (s, 1H), 7.06-7.09 (m, 2H), 7.14-7.24 (m, 3H): 31P (162 MHz, CDCl3) δ 24.35 (s, 1 P), 24.39 (s, 1 P).

後処理

  1. concentrationwas concentrated to dryness
  2. customAfter drying under vacuum

出典と根拠

ORDレコード
ord-b7e8c3d44885490494045fe7a410aca7
出典データセット
uspto-grants-2013_09
特許番号
US08524691B2

関連ノート

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