HCID 22660807、化合物 → HCID 22660783、化合物
反応式
[CH:1]1([NH:7][C:8]2[CH:13]=[CH:12][C:11]([S:14]([NH2:17])(=[O:16])=[O:15])=[CH:10][C:9]=2[N+:18]([O-])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CO.C(OCC)(=O)C.[Pd]>[NH2:18][C:9]1[CH:10]=[C:11]([S:14]([NH2:17])(=[O:15])=[O:16])[CH:12]=[CH:13][C:8]=1[NH:7][CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
5
実験手順
A solution of intermediate 66 (2.56 g, 8.55 mmol) in a mixture of methanol (50 mL) and ethyl acetate (50 mL) was hydrogenated over 10% palladium on carbon (0.14 g) at 50 psi for 2.5 h. The reaction mixture was filtered and concentrated to afford the product as a crude purple-brown foam (2.45 g, 100%). ESI-MS m/e 270.1 (M+1).
後処理
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b5ff9c1eb479476f9a83940f57aad9de
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06803374B2
反応ノート
読み込み中…