Hydrogen Bromide → Phenol, 4-(5-octyl-2-pyridinyl)-

HRID 3931ノート

反応式

HRID 3931 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][N:10]=2)=[CH:5][CH:4]=1.Br.O>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][N:10]=2)=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 962WaterHCID 140699212-(4-Methoxyphenyl)-5-octylpyridine

生成物 1

HCID 1725484Phenol, 4-(5-octyl-2-pyridinyl)-

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

後処理

  1. temperaturethe solution was heated for 15 hours
  2. temperatureunder reflux
  3. extractionthe organic layer was extracted with chloroform
  4. washAfter washing the
  5. extractionextract three times with water
  6. customthe chloroform was removed by distillation
  7. customThe residue was recrystallized from a mixture of acetone and hexane

出典と根拠

ORDレコード
ord-af619c8be0ee4e34923575da7dc53150
出典データセット
uspto-grants-1988_02
特許番号
US04723018

反応ノート

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