Hydrochloric Acid → Ethyl 5-(4-Aminophenyl)-2-Methyl-3-Furoate

HRID 393277ノート

反応式

HRID 393277 の反応式
[CH3:1][C:2]1[O:3][C:4]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].Cl>CCO.[Fe]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([C:4]2[O:3][C:2]([CH3:1])=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:5]=2)=[CH:17][CH:16]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 2742183Ethyl 2-methyl-5-(4-nitrophenyl)furan-3-carboxylate

生成物 1

HCID 2742184Ethyl 5-(4-Aminophenyl)-2-Methyl-3-Furoate収率 89%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 2-methyl-5-(4-nitrophenyl)-3-furanecarboxylate (500 mg, 1.82 mmol), iron powder (325 mesh, 811 mg, 14.5 mmol) and aqueous 1 N HCl solution (0.36 mL, 0.36 mmol) in EtOH (5 mL) was heated to reflux for 2 h. The reaction mixture was filtered and concentrated under reduced pressure to give the title compound (396 mg, 89% yield) as a brown oil.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 2 h
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e7b722fe2a1748cf9baac49ab36e8f4f
出典データセット
uspto-grants-2004_10
特許番号
US06806265B2

反応ノート

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