Cyclohexene → 4-(trifluoromethyl)pyrimidine-5-carboxylic Acid

HRID 393481ノート

反応式

HRID 393481 の反応式
C([O:8][C:9]([C:11]1[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14](Cl)=[N:15][CH:16]=1)=[O:10])C1C=CC=CC=1.C1CCCCC=1>C(O)C.[Pd]>[F:21][C:18]([F:19])([F:20])[C:12]1[C:11]([C:9]([OH:10])=[O:8])=[CH:16][N:15]=[CH:14][N:13]=1

参加物

5

反応物 2

HCID 8079CyclohexeneHCID 2735989Benzyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

生成物 1

HCID 116080754-(trifluoromethyl)pyrimidine-5-carboxylic Acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-chloro-4-trifluoromethyl-5-pyrimidine carboxylic acid benzyl ester in cyclohexene (3 mL, 30 mmole) and ethanol (9 mL) was treated with 10% palladium on carbon and the resulting mixture was heated to reflux for 1 h. The mixture was cooled to room temperature and filtered through a pad of Celite and concentrated to give a quantitative yield of a gummy, off-white solid. LR ES MS (C6H3F3N2O2): 191 (M−H).

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux for 1 h
  3. filtrationfiltered through a pad of Celite
  4. concentrationconcentrated
  5. customto give a quantitative yield of a gummy, off-white solid

出典と根拠

ORDレコード
ord-bf9f683b458c4e4883e262084cc30e3f
出典データセット
uspto-grants-2004_10
特許番号
US06806365B2

反応ノート

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