7-Benzyloxy-4-chloro-6-methoxyquinoline hydrochloride → 4-Chloro-6-methoxyquinolin-7-ol
反応式
Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[CH:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[Cl:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([OH:9])=[C:11]([O:21][CH3:22])[CH:12]=2)[N:17]=[CH:16][CH:15]=1参加物
3
実験手順
A solution of 7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride (6.8 g, 20 mmol) in TFA (80 ml) was heated at reflux for 5.5 hours. The volatiles were removed by evaporation, the residue suspended in water and the mixture was adjusted to pH7 with a saturated aqueous sodium hydrogen carbonate solution. The resulting solid was collected by filtration, washed with water, ether and dried under vacuum to give 4-chloro-7-hydroxy-6-methoxyquinoline (4.1 g, 98%).
後処理
- temperatureat reflux for 5.5 hours
- customThe volatiles were removed by evaporation
- filtrationThe resulting solid was collected by filtration
- washwashed with water, ether
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-a07b263e1f9c44569f87333c7a7d219b
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06809097B1
反応ノート
読み込み中…