5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione → HCID 22646513、化合物

HRID 393655

反応式

HRID 393655 の反応式
[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][C:4]=1[O:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)#[N:2].[CH3:20][C:21]1([CH3:32])[O:26][C:25](=[O:27])[C:24](=[CH:28]OC)[C:23](=[O:31])[O:22]1>C(O)C>[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH:7][CH:28]=[C:24]2[C:23](=[O:31])[O:22][C:21]([CH3:20])([CH3:32])[O:26][C:25]2=[O:27])=[CH:5][C:4]=1[O:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)#[N:2]

参加物

4

反応物 2

HCID 1521115-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 2328004-Cyano-3-(3-morpholinopropoxy)aniline

生成物 1

HCID 22646513HCID 22646513、化合物収率 74.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Cyano-3-(3-morpholinopropoxy)aniline (2.5 g, 9.6 mmol) and 2,2-dimethyl-5-methoxymethylene-1,3-dioxane-4,6-dione (2.4 g, 13 mmol), (Montatsh. Chem. 1967, 98, 564), in ethanol (40 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the solid was collected by filtration to give 5-((4-cyano-3-(3-morpholinopropoxy)anilino)methylene)-2,2-dimethyl-1,3-dioxane-4.6-dione (2.96 g, 74%).

後処理

  1. temperatureat reflux for 2 hours
  2. temperatureto cool
  3. filtrationthe solid was collected by filtration

出典と根拠

ORDレコード
ord-7d50f465da16440aac820b9036fdad66
出典データセット
uspto-grants-2004_10
特許番号
US06809097B1

関連ノート

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