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Sodium Hydroxide → Ethyl (3S)-piperidine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl (S)-3-Piperidinecarboxylate D-Tartrate | HCID 14183617 | — |
| 生成物 | Ethyl (3S)-piperidine-3-carboxylate | HCID 187784 | 112.8% |
反応手順
To 13.0 g of ethyl (3S)-3-piperidinecarboxylate D(−)-tartarate which was synthesized following the method of P. Magnus, et al. [J. Org. Chem. Vol. 56, 1166-1170 (1991)], 3N aqueous sodium hydroxide solution was added to render the former basic, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 7.50 g of the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06809108B1 |
| 出典データセット | uspto-grants-2004_10 |
| ORD ID | ord-2634489c1dd6442fbb237c8936f4cd17 |
| 出典メモ | uspto-grants-2004_10 |