反应详情

To 13.0 g of ethyl (3S)-3-piperidinecarboxylate D(−)-tartarate which was synthesized following the method of P. Magnus, et al. [J. Org. Chem. Vol. 56, 1166-1170 (1991)], 3N aqueous sodium hydroxide solution was added to render the former basic, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 7.50 g of the title compound was obtained.

1. extractionfollowed by extraction with chloroform
2. dry with materialdrying over anhydrous magnesium sulfate
3. distillationDistilling the solvent off under reduced pressure