Methyl iodide → 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

HRID 394094

反応式

HRID 394094 の反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)[CH3:2].[CH3:10][I:11]>CC(C)=O>[I-:11].[CH2:1]([N+:3]1([CH3:10])[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1)[CH3:2]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 771591-Ethylpiperidin-4-one

生成物 1

HCID 110975681-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 100 g (0.789 mol) of 1-ethyl-4-oxopiperidine in 1000 mL of acetone was stirred at rt in a water bath. To this was added 62.2 mL (142 g, 1 mol) of methyl iodide, dropwise at such a rate to keep the temperature below 30 degrees. A precipitate developed within minutes and the mixture was stirred at rt for 4 h. The mixture was filtered and the precipitate washed with acetone and dried to afford the title compound as a white solid. Mass spectrum (ESI) 142 (M+).

後処理

  1. customthe temperature below 30 degrees
  2. waitA precipitate developed within minutes
  3. filtrationThe mixture was filtered
  4. washthe precipitate washed with acetone
  5. customdried

出典と根拠

ORDレコード
ord-87a7885c7a4544d6b1fd2241658e57ce
出典データセット
uspto-grants-2004_10
特許番号
US06809199B2

関連ノート

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