Methyl 4-chlorobenzoate → Lithium 4-chlorobenzoate

HRID 3942

反応式

HRID 3942 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][CH:3]=1.C[Si](C)(C)[O-].[Li+:17]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O-:8])=[O:7])=[CH:4][CH:3]=1.[Li+:17]

参加物

4

反応物 2

HCID 14307Methyl 4-chlorobenzoateHCID 74821Lithium trimethylsilanolate

生成物 1

HCID 19205643Lithium 4-chlorobenzoate収率 46.4%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The procedure of Example 1 was followed using methyl 4-chlorobenzoate (4.3 g, 25.2 mmol), lithium trimethylsilanolate (2.42 g, 25.2 mmol), and dry toluene (100 mL) and overnight heating at reflux. Lithium 4-chlorobenzoate (1.9 g, 46% yield) was isolated as a white solid: 1H NMR (D2O) δ 7.4 (ABq, Δν1-3 =31 Hz, J=9 Hz, Ar--H's, 2 H). This solid was contaminated with a small amount of lithium trimethylsilanolate.

後処理

  1. temperatureheating
  2. temperatureat reflux

出典と根拠

ORDレコード
ord-6e6d66be1f8a416f914ae00c5029e6a2
出典データセット
uspto-grants-1988_02
特許番号
US04723016

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