Lithium Hydroxide → [Rac]-2-ethoxy-3-(4-{2-[2-(4-isopropyl-phenyl)-thiazol-4-yl]-ethoxy}-2-methyl-phenyl)-propionic acid
反応式
C([O:3][C:4](=[O:34])[CH:5]([O:31][CH2:32][CH3:33])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=3)[S:19][CH:20]=2)=[CH:9][C:8]=1[CH3:30])C.[Li+].[OH-]>>[CH2:32]([O:31][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=3)[S:19][CH:20]=2)=[CH:9][C:8]=1[CH3:30])[C:4]([OH:34])=[O:3])[CH3:33]参加物
3
実験手順
In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-(4-{2-[2-(4-isopropyl-phenyl)-thiazol-4-yl]-ethoxy}-2-methyl-phenyl)-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-(4-{2-[2-(4-isopropyl-phenyl)-thiazol-4-yl]-ethoxy}-2-methyl-phenyl)-propionic acid as colorless liquid.
後処理
- customdescribed in example 10 d
出典と根拠
- ORDレコード
- ord-a448d760ca444db8a4a12211e86c3668
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06809110B2
反応ノート
読み込み中…