Lithium Hydroxide → [Rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid
反応式
C([O:3][C:4](=[O:30])[CH:5]([O:27][CH2:28][CH3:29])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[S:18][CH:19]=2)=[CH:9][C:8]=1[CH3:26])C.[Li+].[OH-]>>[CH2:28]([O:27][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[S:18][CH:19]=2)=[CH:9][C:8]=1[CH3:26])[C:4]([OH:30])=[O:3])[CH3:29]参加物
3
実験手順
In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid as colorless crystals.
後処理
- customdescribed in example 10 d