Sulfuric Acid → 4-(Benzyloxy)-1-bromo-2-fluorobenzene
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1.[Br:16]N1C(=O)CCC1=O.S(=O)(=O)(O)O>>[Br:16][C:7]1[CH:6]=[CH:5][C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:3][C:2]=1[F:1]参加物
4
実験手順
In analogy to the procedure described in example 23 b], 1-fluoro-3-(phenylmethoxy)-benzene (for the preparation of 1-fluoro-3-(phenylmethoxy)-benzene see: A. A. Durrani, J. H. P. Tyrnan, J. Chem. Soc., Perkin Trans. 1 1979, 8, 2079-2087) was treated with N-bromosuccinimide in the presence of concentrated sulfuric acid to give 1-bromo-2-fluoro-4-(phenylmethoxy)-benzene as colorless oil.
出典と根拠
- ORDレコード
- ord-21d277e68ae14418b09787ea0d199902
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06809110B2
反応ノート
読み込み中…